The latest world outbreak is a phenomenon that has attracted global attention, especially in relation to public health. One of the most striking outbreaks is the COVID-19 pandemic, which has changed the way people live and interact. The pandemic began in late 2019 and grew rapidly throughout 2020, causing health, economic and social crises across the world. Since then, several virus variants have emerged, such as Delta and Omicron, that have shown the ability to spread more quickly and evade immunity generated by vaccines or previous infections. This has sparked rapid vaccine development, including mRNA vaccines such as Pfizer and Moderna, as well as other virus-based vaccines such as Sinovac. Countries around the world are racing to vaccinate their populations, in hopes of controlling the spread of the virus. Another outbreak that has received attention is monkeypox, a disease caused by a virus similar to smallpox. Although previously considered rare, monkeypox cases increased in various countries in 2022. Transmission occurs through close contact with infected individuals, as well as through infected animals. Governments around the world are taking preventive measures, including monitoring and developing vaccines to combat the spread of this disease. Apart from that, ISR (Influenza Respiratory Syndrome) is also a concern in the world of health. Bird flu caused by the H5N1 virus continues to threaten, especially in Asian countries. Symptoms of this disease are similar to the common cold, but can cause serious complications and death. Research on vaccines and treatments for influenza remains a top priority for scientists and health institutions. From a mental health perspective, disease outbreaks and the uncertainty they cause have a significant impact on society. Many people experience anxiety, depression and mental stress due to social isolation and concerns about their health. Mental health support programs are beginning to be introduced in an effort to help individuals overcome these challenges. Changes in people’s lifestyles can also be seen. Increasing awareness of hygiene, wearing masks and vaccinations are becoming part of the new culture. E-commerce, online education, and remote work are becoming commonplace, driving further digitalization. Governments in various countries are working to improve their health systems, keeping in mind the lessons learned from the outbreak. Investment in research and drug development and vaccination is the main focus, with the hope of being better prepared to face future outbreaks. All these dynamics demonstrate the importance of global cooperation and speed of response in dealing with the latest world outbreak. Through synergy between the government, health institutions and the community, it is hoped that the spread of the epidemic can be suppressed and global health can be maintained.